← All skills

bio-variant-calling-clinical-interpretation

75 / 100 · Review before installing

Check before installing.

By lilinji/GeneTind-Life-Skills (GitHub) · other · 17 stars · scanned at commit 908229c

Classify variant clinical significance with the ACMG/AMP germline framework and its 2018-2025 ClinGen refinements (graded PVS1 decision tree, PM2 downgraded to Supporting, PP5/BP6 retired, calibrated PP3/BP4, Bayesian points), the AMP/ASCO/CAP somatic tiers and ClinGen oncogenicity system, ClinVar star-rating and gnomAD grpmax filtering-AF interpretation. Use when deciding germline-vs-somatic framework, applying current (not flat-2015) ACMG points, checking for a gene-specific VCEP specificatio…

Works with any agent that supports SKILL.md skills.

What this skill can do

Safer alternatives

Low-risk skills in the same category (other) that look related. Check that one does what you need.

• 95 Low riskclinical-variant-prioritizerClawBio/ClawBio · 1,182 stars
• 85 Low riskbio-clinical-databases-gnomad-frequenciesdiegosouzapw/awesome-omni-skill · 66 stars
• 95 Low riskngs-dna-variant-callingopenai/plugins · 7,922 stars

Install

Paste this into your terminal. It downloads exactly the version we scanned, not whatever is newest.

if [ -e ~/.agents/skills/'bio-variant-calling-clinical-interpretation' ] || [ -L ~/.agents/skills/'bio-variant-calling-clinical-interpretation' ]; then echo 'A skill folder named bio-variant-calling-clinical-interpretation already exists — not replacing it' >&2; false; else d=$(mktemp -d) && git clone --quiet --filter=blob:none --no-checkout 'https://github.com/lilinji/GeneTind-Life-Skills' "$d" && git -C "$d" checkout --quiet '908229c955510a1841b216e8bf58f6b22818d4dc' -- 'skills/bio-variant-calling-clinical-interpretation' && mkdir -p ~/.agents/skills && cp -R "$d"/'skills/bio-variant-calling-clinical-interpretation' ~/.agents/skills/'bio-variant-calling-clinical-interpretation' && rm -rf "$d"; fi

Codex reads ~/.agents/skills directly. For Claude Code, Cursor, Copilot, Gemini CLI, Antigravity or OpenCode, also link it. For Claude Code: ln -s ~/.agents/skills/'bio-variant-calling-clinical-interpretation' ~/.claude/skills/'bio-variant-calling-clinical-interpretation' (other agents: ~/.cursor/skills, ~/.copilot/skills, ~/.gemini/skills, ~/.gemini/config/skills, ~/.config/opencode/skills). Or install through the finder skill, which does both.

Badge for your README

The badge for lilinji/GeneTind-Life-Skills shows the score of its lowest-scoring skill.

[![SkillTrust](https://zalavijaysinh.github.io/skilltrust/badges/lilinji/GeneTind-Life-Skills.svg)](https://zalavijaysinh.github.io/skilltrust/repos/lilinji/GeneTind-Life-Skills/)

Score history