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solublempnn

80 / 100 · Low risk

Fine to try.

By aipoch/open-science (GitHub) · research · 5,526 stars · scanned at commit c4ae79b

Inverse-fold a backbone with SolubleMPNN — ProteinMPNN retrained on a soluble-PDB subset (Dauparas et al. 2022) — for sequences biased toward cytosolic expression and reduced aggregation. Reach for this skill when designs from vanilla ProteinMPNN are aggregating or going to inclusion bodies, when redesigning a membrane-adjacent fold for soluble expression, or when an E. coli expression screen is the next step.

Works with any agent that supports SKILL.md skills.

What this skill can do

Install

Paste this into your terminal. It downloads exactly the version we scanned, not whatever is newest.

if [ -e ~/.agents/skills/'solublempnn' ] || [ -L ~/.agents/skills/'solublempnn' ]; then echo 'A skill folder named solublempnn already exists — not replacing it' >&2; false; else d=$(mktemp -d) && git clone --quiet --filter=blob:none --no-checkout 'https://github.com/aipoch/open-science' "$d" && git -C "$d" checkout --quiet 'c4ae79ba6ca5c97dcb1fb27518acda85319d7115' -- 'resources/skills/solublempnn' && mkdir -p ~/.agents/skills && cp -R "$d"/'resources/skills/solublempnn' ~/.agents/skills/'solublempnn' && rm -rf "$d"; fi

Codex reads ~/.agents/skills directly. For Claude Code, Cursor, Copilot, Gemini CLI, Antigravity or OpenCode, also link it. For Claude Code: ln -s ~/.agents/skills/'solublempnn' ~/.claude/skills/'solublempnn' (other agents: ~/.cursor/skills, ~/.copilot/skills, ~/.gemini/skills, ~/.gemini/config/skills, ~/.config/opencode/skills). Or install through the finder skill, which does both.

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