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esmfold2

80 / 100 · Low risk

Fine to try.

By aipoch/open-science (GitHub) · research · 5,526 stars · scanned at commit c4ae79b

Biohub ESMFold2 / ESMFold2-Fast all-atom co-folding (Candido et al. 2026, github.com/Biohub/esm). Single-sequence and MSA modes; protein, DNA, RNA, ligand (CCD/SMILES), modified residues. FoldBench Ab-Ag 50-55%, PPI 70-77% DockQ-pass. Also covers the ESMC-{300M,600M,6B} protein language models from the same release: masked-LM logits, hidden states, mutation scoring, contact prediction, and the SAE interpretability head. MIT-licensed weights on HuggingFace org `biohub`. Use this skill when: (1) …

Works with any agent that supports SKILL.md skills.

What this skill can do

Install

Paste this into your terminal. It downloads exactly the version we scanned, not whatever is newest.

if [ -e ~/.agents/skills/'esmfold2' ] || [ -L ~/.agents/skills/'esmfold2' ]; then echo 'A skill folder named esmfold2 already exists — not replacing it' >&2; false; else d=$(mktemp -d) && git clone --quiet --filter=blob:none --no-checkout 'https://github.com/aipoch/open-science' "$d" && git -C "$d" checkout --quiet 'c4ae79ba6ca5c97dcb1fb27518acda85319d7115' -- 'resources/skills/esmfold2' && mkdir -p ~/.agents/skills && cp -R "$d"/'resources/skills/esmfold2' ~/.agents/skills/'esmfold2' && rm -rf "$d"; fi

Codex reads ~/.agents/skills directly. For Claude Code, Cursor, Copilot, Gemini CLI, Antigravity or OpenCode, also link it. For Claude Code: ln -s ~/.agents/skills/'esmfold2' ~/.claude/skills/'esmfold2' (other agents: ~/.cursor/skills, ~/.copilot/skills, ~/.gemini/skills, ~/.gemini/config/skills, ~/.config/opencode/skills). Or install through the finder skill, which does both.

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