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solublempnn

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By adaptyvbio/protein-design-skills (GitHub) · design · 173 stars · scanned at commit 59dd633

Solubility-optimized protein sequence design using SolubleMPNN. Use this skill when: (1) Designing for E. coli expression, (2) Optimizing solubility of designed proteins, (3) Reducing aggregation propensity, (4) Need high-yield expression, (5) Avoiding inclusion body formation. For standard design, use proteinmpnn. For ligand-aware design, use ligandmpnn.

Works with any agent that supports SKILL.md skills.

What this skill can do

Safer alternatives

Low-risk skills in the same category (design) that look related. Check that one does what you need.

• 95 Low risksolublempnnlilinji/GeneTind-Life-Skills · 17 stars

Install

Paste this into your terminal. It downloads exactly the version we scanned, not whatever is newest.

if [ -e ~/.agents/skills/'solublempnn' ] || [ -L ~/.agents/skills/'solublempnn' ]; then echo 'A skill folder named solublempnn already exists — not replacing it' >&2; false; else d=$(mktemp -d) && git clone --quiet --filter=blob:none --no-checkout 'https://github.com/adaptyvbio/protein-design-skills' "$d" && git -C "$d" checkout --quiet '59dd63374314baa2fb1f9864f190775bd7466647' -- 'skills/solublempnn' && mkdir -p ~/.agents/skills && cp -R "$d"/'skills/solublempnn' ~/.agents/skills/'solublempnn' && rm -rf "$d"; fi

Codex reads ~/.agents/skills directly. For Claude Code, Cursor, Copilot, Gemini CLI, Antigravity or OpenCode, also link it. For Claude Code: ln -s ~/.agents/skills/'solublempnn' ~/.claude/skills/'solublempnn' (other agents: ~/.cursor/skills, ~/.copilot/skills, ~/.gemini/skills, ~/.gemini/config/skills, ~/.config/opencode/skills). Or install through the finder skill, which does both.

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