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ligandmpnn

75 / 100 · Review before installing

Check before installing.

By adaptyvbio/protein-design-skills (GitHub) · design · 173 stars · scanned at commit 59dd633

Ligand-aware protein sequence design using LigandMPNN. Use this skill when: (1) Designing sequences around small molecules, (2) Enzyme active site design, (3) Ligand binding pocket optimization, (4) Metal coordination site design, (5) Cofactor binding proteins. For standard protein design, use proteinmpnn. For solubility optimization, use solublempnn.

Works with any agent that supports SKILL.md skills.

What this skill can do

Safer alternatives

Low-risk skills in the same category (design) that look related. Check that one does what you need.

• 95 Low riskligandmpnnlilinji/GeneTind-Life-Skills · 17 stars
• 100 Low riskprotein-design-ligandmpnnai4nucleome/BioMaster · 118 stars

Install

Paste this into your terminal. It downloads exactly the version we scanned, not whatever is newest.

if [ -e ~/.agents/skills/'ligandmpnn' ] || [ -L ~/.agents/skills/'ligandmpnn' ]; then echo 'A skill folder named ligandmpnn already exists — not replacing it' >&2; false; else d=$(mktemp -d) && git clone --quiet --filter=blob:none --no-checkout 'https://github.com/adaptyvbio/protein-design-skills' "$d" && git -C "$d" checkout --quiet '59dd63374314baa2fb1f9864f190775bd7466647' -- 'skills/ligandmpnn' && mkdir -p ~/.agents/skills && cp -R "$d"/'skills/ligandmpnn' ~/.agents/skills/'ligandmpnn' && rm -rf "$d"; fi

Codex reads ~/.agents/skills directly. For Claude Code, Cursor, Copilot, Gemini CLI, Antigravity or OpenCode, also link it. For Claude Code: ln -s ~/.agents/skills/'ligandmpnn' ~/.claude/skills/'ligandmpnn' (other agents: ~/.cursor/skills, ~/.copilot/skills, ~/.gemini/skills, ~/.gemini/config/skills, ~/.config/opencode/skills). Or install through the finder skill, which does both.

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